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Binding Site Defined

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Off-site Binding Site Links, User Submitted

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Fri Jun 26

• Pocket-Finder: Pocket Detection
• Locating mammalian transcription factor binding sites: A survey of computational and experimental techniques ? Genome Research

Sat Apr 18

• In Vitro - Exploring the binding site of acetogenin in the ND1 subunit of bovine mitochondrial complex I - Kyoto University Japan JP - 2009: An acetogenin photo-cross-li nks to the ND1 subunit of bovine heart mitochondrial NADH?ubiquinon e oxidoreductase (complex I) with high specificity. The ND1 subunit constructs the inhibitor binding domain in bovine heart mitochondrial complex I. To identify the binding site of the ACG ([125I]TDA) in the ND1 subunit, we carried out limited proteolysis of the subunit cross-linked by [125I]TDA using various proteases. Our results revealed that the cross-linked residue is located within the region of the 4th to 5th transmembrane helices (Val144?Glu192 ) of the subunit. It is worth noting that an excess amount of short-chain ubiquinones such as ubiquinone-2 (Q2) and 2-azido-Q2 suppressed the cross-linking by [125I]TDA in a concentration- dependent way. An inhibitor (acetogenin) and ubiquinone competitively bind to the enzyme. Not all inhibitors acting at the terminal electron transfer step of complex I necessarily bind to the ubiquinone binding site itself.

Thu Feb 26

• Catalytic Site Atlas

Sun Nov 2

• http://compare prospector.sta nford.edu/seq. fasta

Tue Sep 2

• SuperSite - Home - Dictionary of metabolite and drug binding sites in proteins

Thu Aug 28

• Villoutreix Links: Free Structural Bioinformatics and VLS tools

Fri Aug 15

• LigASite database of binding sites

Wed Aug 13

• The MoD Tools - Weeder WeederH RNAProfile
• finding tf binding sites in dna sequences: a template based approach

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Off-site Binding Site Research Links

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