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Sun Nov 16

• Now - The Rest of the Genome - NYTimes.com: "In 1944, for example, the Netherlands suffered a brutal famine [...] the researchers reported that today they still have fewer epigenetic marks than their siblings. They suggest that pregnant mothers could not supply their children with the raw ingredients for epigenetic marks. In at least some cases, these new epigenetic patterns may be passed down to future generations. Eva Jablonski and Gal Raz of Tel Aviv University in Israel assemble a list of 101 cases in which a trait linked to an epigenetic change was passed down through three generations For example, Matthew Amway of Washington State University and his colleagues found that exposing pregnant rats to a chemical for killing fungus disrupted the epigenetic marks in the sperm of male embryos. The embryos developed into adult rats that suffered from defective sperm and other disorders, like cancer. The males passed down their altered epigenetic marks to their own offspring, which passed them down to yet another generation.&qu ot;

Wed Nov 12

• Now - The Rest of the Genome - NYTimes.com: "bestiary " graphic is very informative

Mon Nov 10

• Now - The Rest of the Genome - NYTimes.com: New work in the field of genetics suggests that only a small portion of our DNA actually codes for proteins. Some genes that do code for proteins seem to be templates for more than one protein. This article focusses a lot on the epigenome and epigenomics describing how gene expression can be controlled and modified. There is much mention of non-coding RNA and what function it serves. Some feel most of our DNA is inert "junk&quo t; injected into our genome by viruses and serves no purpose. A new level of variability has been added to the genome including how genetic expression can be influenced by environment and how this expression can be heritable

Fri Nov 7

• YouTube - From DNA to Protein

Tue Nov 4

• Early-stage gene transcription creates access to DNA: The lecture in Biological Molecules on 'Ideas about transcription& #039; stated that RNA polymerase is used in the initiation stage of transcription. This recent research has found that "The process of transcribing non-coding RNAs is required for the eventual production of the protein-encodi ng RNA."

Fri Oct 31

• Re-positioning genes to the nuclear envelope in mammalian cells: impact on transcription.: This article tells of an experiment that was conducted that showed that nuclear position can directly affect genetic function.

Tue Oct 28

• "Loss of putative tumor suppressor EI24/PIG8 confers resistance to etoposide.": "rget gene EI24/PIG8 is lost in invasive breast cancers,sugges ting that EI24/PIG8 is a tumor suppressor that prevents tumor spreading, and partially mediates p53-attributed tumor suppressor activity. EI24/PIG8 also has pro-apoptotic activity indicating that loss of EI24/PIG8 may modulate sensitivity to chemotherapy. Here it is demonstrated that suppression of EI24/PIG8 in fibroblasts and breast cancer cells significantly inhibits the apoptotic response to etoposide treatment. These findings suggest that loss of EI24/PIG8 contributes significantly to resistance of cells to chemotherapeut ic agents that function through p53, and identify the EI24/PIG8 status as a potentially new prognostic marker of chemotherapy responsiveness ."

Tue Jul 15

• BioConductor

Mon Apr 28

• RNAi focus from Nature Reviews: RNA interference - Animations: Animation explanation of the expression of an RNA interference gene.

Thu Apr 17

• Carl Zimmer's Dissection: The More We Know About Genes, the Less We Understand

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